Evaluation of physiological and immunological parameters in the offspring born from passively smoking rats treated with neuropeptides
- Авторлар: Smolyagin A.I.1, Simbirtsev A.S.2, Mikhailova I.V.1, Ermolina E.V.1, Isengulova A.A.1, Pushkareva L.A.1, Kuzmicheva N.А.1, Filippova Y.V.1, Chaynikova I.N.1, Miroshnichenko I.V.1
-
Мекемелер:
- Orenburg State Medical University
- State Research Institute of Highly Pure Biopreparations
- Шығарылым: Том 19, № 1-4 (2022)
- Беттер: 75-79
- Бөлім: Articles
- URL: https://cijournal.ru/1684-7849/article/view/623116
- DOI: https://doi.org/10.17816/CI2022221-4-12
- ID: 623116
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
The results of physiological and immunological studies of rat pups born from females who were exposed to passive smoking and exposure to tetrapeptide KK1 during pregnancy are presented. From the 1st to the 21st postnatal days, the somatic and sensorimotor development of offspring was studied using a set of tests developed at the P.K. Anokhin Institute of Normal Physiology. The level of cytokines IFN gamma and IL-6 produced by rat splenocytes was studied in culture fluid by the ELISA method. In baby rats born from passively smoking females, compared with animals born from non-smoking rats, a decrease in the weight of baby rats was found, as well as a delay in the timeliness of somatic and sensorimotor development. The introduction of the peptide KK 1 non-smoking females increases the index of timeliness of somatic and sensorimotor development.
The results obtained show an induced variant of secondary immunodeficiency in baby rats born from passively smoking rats during pregnancy. Administration of the KK1 peptide to non-smoking rats did not change the immunological parameters of the baby rats. On the contrary, the production of peptide KK1 by pregnant rats who smoked was accompanied by changes in the number of cells in lymphoid organs and the production of cytokines by splenocytes in the born rats.
Негізгі сөздер
Толық мәтін
Авторлар туралы
Alexander Smolyagin
Orenburg State Medical University
Хат алмасуға жауапты Автор.
Email: probllab.orenburg@mail.ru
md, professor, honored worker of the higher school of the russian federation, professor of the department of clinical laboratory diagnostics
Ресей, 460000, Orenburg, Sovetskaya str., 6Andrey Simbirtsev
State Research Institute of Highly Pure Biopreparations
Email: cytokines@yandex.ru
corresponding member of the Russian academy of sciences, professor
Ресей, St.PetersburgIrina Mikhailova
Orenburg State Medical University
Email: cytokines@yandex.ru
doctor of biological sciences, associate professor, head of the department of pharmaceutical chemistry
Ресей, 460000, Orenburg, Sovetskaya str., 6Evgenia Ermolina
Orenburg State Medical University
Email: cytokines@yandex.ru
candidate of biological sciences, biologist of the immunological laboratory
Ресей, 460000, Orenburg, Sovetskaya str., 6Ainagul Isengulova
Orenburg State Medical University
Email: cytokines@yandex.ru
candidate of medical sciences, associate professor, associate professor of the department of normal physiology
Ресей, 460000, Orenburg, Sovetskaya str., 6Ludmila Pushkareva
Orenburg State Medical University
Email: cytokines@yandex.ru
postgraduate student of the department of normal physiology
Ресей, 460000, Orenburg, Sovetskaya str., 6Natalia Kuzmicheva
Orenburg State Medical University
Email: cytokines@yandex.ru
senior lecturer of the department of pharmaceutical chemistry
Ресей, 460000, Orenburg, Sovetskaya str., 6Yulia Filippova
Orenburg State Medical University
Email: cytokines@yandex.ru
candidate of medical sciences, associate professor of the department of pharmaceutical chemistry
Ресей, 460000, Orenburg, Sovetskaya str., 6Irina Chaynikova
Orenburg State Medical University
Email: cytokines@yandex.ru
md, professor of the department of normal physiology
Ресей, 460000, Orenburg, Sovetskaya str., 6Igor Miroshnichenko
Orenburg State Medical University
Email: cytokines@yandex.ru
professor, head of the department of normal physiology
Ресей, 460000, Orenburg, Sovetskaya str., 6Әдебиет тізімі
- Волчегорский И.А., Долгушин И.И., Колесников О.Л., Цейликман В.Э. Экспериментальное моделирование и лабораторная оценка адаптивных реакций организма. – Челябинск: ЧГПУ, 2000. – C. 167. Volchegorsky I.A., Dolgushin I.I., Kolesnikov O.L., Tseilikman V.E. [Experimental modeling and laboratory evaluation of adaptive reactions of the organism]. Chelyabinsk : Chelyabinsk state pedagogical University, 2000. P.167. Russian.
- Дейко Р.Д., Штрыголь С.Ю., Колобов А.А., Симбирцев А.С. Церебропротекторные свойства и протеолитическая устойчивость пептидов, гомологичных первичной последовательности участка АКТГ15-18 (экспериментальное исследование) // Цитокины и воспаление. – 2015. – Т. 14, № 2. – С. 65-69. Deiko R.D., Shtrygol S.Yu., Kolobov A.A., Simbirtsev A.S. Cerebroprotective properties of the original peptides homologous to ACTH15-18 primary sequence (experimental study). Cytokines and Inflammation, 2015, No. 14, Р. 65-69. Russian.
- Захарчук Н.В., Невзорова В.А., Шуматов В.Б., Шестакова Н.В., Гончар Е.Ю. Субстанция в механизмах развития церебральной дисфункции при хроническом табакокурении //Тихоокеанский медицинский журнал. – 2016. – № 2. – С. 62-66. Zakharchuk N.V., Nevzorova V.A., Shumatov V.B., Shestakova N.V., Gonchar E.Yu. [Substance P in the mechanisms of the development of cerebral dysfunction in chronic tobacco Smoking] //Pacific medical journal. 2016. No. 2. P. 62-66. Russian.
- Кудина О.В., Штрыголь С.Ю., Колобов А.А., Ларьяновская Ю.Б. Влияние олигопептидов - гомологов фрагмента актг15-18 на состояние печени и надпочечников крыс на модели острого иммобилизационного стресса // Обзоры по клинической фармакологии и лекарственной терапии. – 2017. – Т. 15, № 4. – C. 30-37. Kudina O.V., Shtrygol S.Yu., Kolobov A.A., Laryanovskaya Yu.B. The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress. Reviews on Clinical Pharmacology and Drug Therapy, 2017, Vol. 15, No. 4, P. 30-37. Russian.
- Толкач П.Г., Башарин В.А., Гребенюк А.Н., Колобов А.А. Оценка эффективности пептида КК1 для профилактики отдаленных нарушений функций центральной нервной системы после тяжелой интоксикации оксидом углерода в эксперименте // Обзоры по клинической фармакологии и лекарственной терапии, 2015. – Т. 13. – № 3. – С. 29-34. Tolkach P.G., Basharin V.A., Grebenyuk A.N., Kolobov A.A. [Experimental assessment of the KK1 peptide effectiveness for prevention of CNS delayed impairments after acute intoxication with carbon monoxide]// Reviews of clinical pharmacology and drug therapy, 2015. – Vol.13. No. 3, P. 29-34. Russian.
- Толкач П.Г., Башарин В.А., Соловьева Т.С., Слуцкая Д.Р. Сравнительная эффективность нейропептидов КК1 и семакса для терапии поражений центральной нервной системы после тяжелого отравления оксидом углерода // Вестник Российской военно-медицинской академии. 2016. – № 2 (54). – С. 131-137. Tolkach P.G., Basharin A.V., Solovyeva T.S., Slutskaya D.R. [Comparative effectiveness of neuropeptides KK1 and semax for therapy impairment of central nervous system after acute intoxication of carbon monoxide]//Vestnik of Russian military medical Academy. 2016. No. 2 (54). P. 131-137. Russian.
- Тюлькова Е.И., Ватаева Л.А., Самойлов М.О., Отеллин В.А. Механизмы формирования реакций мозга на действие гипобарической гипоксии в различные сроки пренатального периода развития у крыс // Журнал акушерства и женских болезней. – 2010. – Т. LIX, № 4. – С. 99-110. Tiul’kova E.I., Vataeva L.A., Samoĭlov M.O., Otellin V.A. [The mechanisms of hypobaric hypoxia-induced alteration in brain development influence of gestational age at exposur]//Journal of obstetrics and women’s diseases. 2010. T. LIX. No. 4. P. 99-110. Russian.
- Strzelak, A., Ratajczak, A., Adamiec, A., & Feleszko, W. (2018). Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. International Journal of Environmental Research and Public Health, 15(5), 1033.
Қосымша файлдар
