Impact of comorbid pathology on the cytokine cascade in the population of a large industrial city (using Chelyabinsk as an example)
- Авторлар: Simbirtsev A.S.1, Ryabova L.V.2, Savchuk K.S.1
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Мекемелер:
- Saint-Petersburg Pasteur Institute
- South Ural State Medical University
- Шығарылым: Том 20, № 4 (2023)
- Беттер: 29-34
- Бөлім: Original Study Articles
- URL: https://cijournal.ru/1684-7849/article/view/630933
- DOI: https://doi.org/10.17816/CI630933
- ID: 630933
Дәйексөз келтіру
Аннотация
BACKGROUND: The steady increase in the number of patients with comorbid pathology in large industrial cities necessitates the study of the immune response in this category of patients.
AIM: To investigate the cytokine profile of residents of a large industrial city (using Chelyabinsk as an example) depending on the presence of comorbid pathology (type 2 diabetes mellitus, obesity, hypertension).
MATERIALS AND METHODS: The cross-sectional study included 61 people, including 39 people with type 2 diabetes mellitus and 22 clinically healthy volunteers. The multiplex assessment method was used to evaluate the concentrations of 11 cytokines in the blood serum: GM-CSF, IFN-γ, IL-2, IL-4, IL-5, IL-8, IL-12p70, IL-13, IL-17A, MIP-1β, TNF-α (pg/ml).
RESULTS: Determination of the concentration of cytokines in the blood serum of patients with comorbid pathology in Chelyabinsk revealed a number of features, consisting in the predominance of proinflammatory cytokines and chemokines (IFN-γ, TNF-α, IL-8, MIP-1β, IL-12p70, IL-17A) and a shift in the Th1/Th2 balance towards the proinflammatory phenotype Th1.
CONCLUSIONS: The obtained results confirm the presence of inflammation in comorbid pathology (type 2 diabetes mellitus, obesity, hypertension) in the population of Chelyabinsk.
Негізгі сөздер
Толық мәтін
Авторлар туралы
Andrey Simbirtsev
Saint-Petersburg Pasteur Institute
Email: simbas@mail.ru
ORCID iD: 0000-0002-8228-4240
SPIN-код: 2064-7584
Scopus Author ID: 7003758888
ResearcherId: K-5061-2014
MD, Dr. Sci. (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences
Ресей, Saint PetersburgLiana Ryabova
South Ural State Medical University
Email: lianarabowa@rambler.ru
ORCID iD: 0000-0001-5367-2001
SPIN-код: 7295-2126
MD, Dr. Sci. (Medicine), Professor
Ресей, ChelyabinskKsenia Savchuk
Saint-Petersburg Pasteur Institute
Хат алмасуға жауапты Автор.
Email: ksenyasavchuk@gmail.com
ORCID iD: 0000-0003-4016-1880
SPIN-код: 4974-0009
Ресей, Saint Petersburg
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