Evaluation of the effectiveness of detoxification in the immunorehabilitation of cancer patients

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Abstract

Purpose. Evaluation of the effectiveness of detoxification using enterosorbents in the immunorehabilitation of cancer patients.

Materials and methods. 87 patients with metastatic forms of solid tumors of various localizations with metastatic lesions were examined. The patients were divided into 2 groups: study group (41 patients who received detoxification therapy in addition to standard therapy) and comparison group (46 patients who received only standard therapy). The effectiveness of therapy with these drugs was evaluated after one month by assessing clinical and immunological parameters. The assessment of the state of cellular immunity was carried out by flow cytometry.

Results. Disturbances in the function of the immune system in the form of insufficiency of the cellular effector link of immunity were detected in all examined patients before the start of therapy. The state of the cellular link of immunity was characterized by an increase in the number of transitional and non-classical subsets of monocytes, an increase in the content of T-, B- and NKT-cells, but with a decrease in NK-cells. An increase in the ratio between the number of T-helpers (CD3+CD4+) and the number of cytotoxic T-cells (CD3+CD8+) was observed in the examined patients. Restoration of cell subsets to the level of control values was found in the examined patients after detoxification therapy as part of immunorehabilitation measures. Significant changes in the number of cells in the blood were absent in the comparison group after the therapy which indicated the absence of a complete relief of the systemic inflammatory response.

Conclusion. Chronic toxicosis with the development of a systemic inflammatory reaction on the background of the immune system dysfunctions were found in cancer patients. The use of enterosorbents in complex immunorehabilitation therapy is substantiated and confirmed by the relief of asthenovegetative and dyspeptic syndromes, normalization of the immune system which makes it possible to recommend detoxification therapy during immunorehabilitation measures.

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About the authors

A. A. Savchenko

FGBNU Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», a separate subdivision of the «Research Institute of Medical Problems of the North»

Email: cytokines@yandex.ru

md, professor, head of the laboratory of cellular and molecular physiology and pathology

Russian Federation, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g

E. V. Kasparov

FGBNU Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», a separate subdivision of the «Research Institute of Medical Problems of the North»

Email: cytokines@yandex.ru

md, professor, director of the research institute

Russian Federation, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g

S. A. Borisov

FGBNU Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», a separate subdivision of the «Research Institute of Medical Problems of the North»

Email: cytokines@yandex.ru

junior researcher at the laboratory of cellular and molecular physiology and pathology

Russian Federation, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g

A. A. Masterova

FGBNU Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», a separate subdivision of the «Research Institute of Medical Problems of the North»

Email: cytokines@yandex.ru

junior researcher at the laboratory of cellular and molecular physiology and pathology

Russian Federation, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g

Alexander G. Borisov

FGBNU Federal Research Center «Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences», a separate subdivision of the «Research Institute of Medical Problems of the North»

Author for correspondence.
Email: 2410454@mail.ru

phd, leading researcher at the laboratory of cellular and molecular physiology and pathology

Russian Federation, 660022, Krasnoyarsk, Partizan Zheleznyak str., 3g

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Supplementary files

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1. JATS XML
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2. Рис. 1. Клинические проявления иммунных нарушений обследуемых больных

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3. Рис. 2. Изменения клинических показателей, характеризующих хронический токсикоз

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4. Рис. 3. Динамика параметров иммунной системы при проведении детоксикационных мероприятий Примечание: сравнение исследуемой группы с исходом * – р<0.05, ** – р<0.01, *** – р<0.001; сравнение группы сравнения с исходом # – р<0.05, ## – р<0.01, ### – р<0.001

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Copyright (c) 2023 Savchenko A.A., Kasparov E.V., Borisov S.A., Masterova A.A., Borisov A.G.

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