Regional features of sensitization to various allergens in children with allergic diseases, taking into account the formed exposome
- Authors: Borisov A.G.1, Bychkovskaya S.V.1, Prodeus A.P.2,3, Smirnova S.V.1, Gerasimova T.A.1, Sadovsky I.S.1, Anisimova E.N.1, Skorokhodova T.G.4, Peretyat'ko O.V.1, Tkachenko O.A.4, Kudryavtsev I.V.5, Tyunyakin M.S.1, Zurochka V.A.6, Muravieva N.G.1, Markhaychuk A.Z.7, Fedorov A.S.8, Savchenko A.A.1
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Affiliations:
- Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
- National Medical Research Center for Phthisiopulmonology and Infectious Diseases
- Research Institute of Childhood of the Ministry of Health of the Moscow Region
- ABV Center for Laboratory Technologies
- Institute of Experimental Medicine
- South Ural State University (national research university)
- Children’s Regional Hospital of the Kaliningrad Region
- Regional Clinical Hospital of the Kaliningrad Region
- Issue: Vol 20, No 4 (2023)
- Pages: 35-48
- Section: Original Study Articles
- URL: https://cijournal.ru/1684-7849/article/view/633648
- DOI: https://doi.org/10.17816/CI633648
- ID: 633648
Cite item
Open Access
Access granted
Abstract
BACKGROUND: According to data from the World Health Organisation, up to 40% of the world’s population and up to 35% of the Russian population suffer from allergies. Assessing the impact of the exposome in the population of the Russian Federation is a crucial issue of national public health care, which will provide a personalised approach to the treatment and prevention of allergic diseases in the local population.
AIM: To evaluate the sensitisation profile in children with allergic diseases from different regions of Russia.
MATERIALS AND METHODS: The study included sick children aged 2 to 12 years with allergic manifestations from different regions of the Russian Federation. The concentration of total IgE and allergen-specific immunoglobulins in blood was determined retrospectively on the basis of analyses of results obtained in clinical and diagnostic laboratories performing immunoblotting tests using the Allergy-Q® test system (South Korea).
RESULTS: Sensitisation to allergens mediated by IgE was detected more frequently than in half of the cases (436 people — 58.39%). In the group of household allergens the first place is occupied by cat, then dog and already then house dust. Among respiratory allergens, birch and/or other trees, weeds and mugwort are the leaders. Food sensitisation in children is mainly to milk, egg, fish and seafood.
CONCLUSIONS: The peculiarities of sensitisation revealed in different regions are easily explained by the formed exposomes (due to different climatic conditions, peculiarities of regional vegetation and nutrition). The obtained data can be used to develop measures of prevention, diagnosis and treatment of allergic diseases.
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About the authors
Alexandr G. Borisov
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: 2410454@mail.ru
ORCID iD: 0000-0002-9026-2615
SPIN-code: 9570-2254
MD, Cand. Sci. (Medicine), Leading Research Associate
Russian Federation, KrasnoyarskSnezhana V. Bychkovskaya
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: allergo@medgorod.ru
ORCID iD: 0009-0009-1366-3894
SPIN-code: 5953-6070
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, KrasnoyarskAndrey P. Prodeus
National Medical Research Center for Phthisiopulmonology and Infectious Diseases; Research Institute of Childhood of the Ministry of Health of the Moscow Region
Email: prodeus@mail.ru
ORCID iD: 0000-0001-5435-1859
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Moscow; MoscowSvetlana V. Smirnova
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: svetvita@mail.ru
ORCID iD: 0000-0002-1197-1481
SPIN-code: 4036-6871
MD, Dr. Sci. (Medicine), Professor
Russian Federation, KrasnoyarskTatyana A. Gerasimova
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: 2568136@bk.ru
ORCID iD: 0000-0002-4032-9367
MD
Russian Federation, KrasnoyarskIvan S. Sadovsky
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: sadovskii24@rambler.ru
ORCID iD: 0000-0003-0338-4647
SPIN-code: 3624-9788
MD, Junior Research Associate
Russian Federation, KrasnoyarskElena N. Anisimova
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: foi-543@mail.ru
ORCID iD: 0000-0002-6120-159X
SPIN-code: 4610-7610
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, KrasnoyarskTatyana G. Skorokhodova
ABV Center for Laboratory Technologies
Email: skorohodova@clt-lab.ru
Russian Federation, Krasnoyarsk
Olga V. Peretyat'ko
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: peretyatkoolga@mail.ru
ORCID iD: 0000-0003-1142-3933
SPIN-code: 3723-2874
Cand. Sci. (Biology), Research Associate
Russian Federation, KrasnoyarskOlesya A. Tkachenko
ABV Center for Laboratory Technologies
Email: kdl-zav@dkb24.ru
Russian Federation, Krasnoyarsk
Igor V. Kudryavtsev
Institute of Experimental Medicine
Email: igorek1981@yandex.ru
ORCID iD: 0000-0001-7204-7850
SPIN-code: 4903-7636
Cand. Sci. (Biology)
Russian Federation, Saint PetersburgMaxim S. Tyunyakin
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: maks2001_1990@mail.ru
ORCID iD: 0009-0005-8664-2913
Junior Research Associate
Russian Federation, KrasnoyarskVladimir A. Zurochka
South Ural State University (national research university)
Author for correspondence.
Email: v_zurochka@mail.ru
ORCID iD: 0000-0001-8930-3742
SPIN-code: 3741-6458
MD, Dr. Sci. (Medicine), Professor
Russian Federation, ChelyabinskNatalya G. Muravieva
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: nataljamurawiewa@yandex.ru
ORCID iD: 0000-0002-3587-3341
SPIN-code: 3235-1367
Russian Federation, Krasnoyarsk
Aishat Z. Markhaychuk
Children’s Regional Hospital of the Kaliningrad Region
Email: ayshat.90@rambler.ru
ORCID iD: 0009-0000-4513-2208
Russian Federation, Kaliningrad
Alexander S. Fedorov
Regional Clinical Hospital of the Kaliningrad Region
Email: fedorowww@list.ru
ORCID iD: 0009-0000-8790-5088
SPIN-code: 2757-9177
Russian Federation, Kaliningrad
Andrei A. Savchenko
Research Institute of Medical Problems of the North — a separate division of the Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”
Email: aasavchenko@yandex.ru
ORCID iD: 0000-0001-5829-672X
SPIN-code: 3132-8260
MD, Dr. Sci. (Medicine), Professor
Russian Federation, KrasnoyarskReferences
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