Features of innate and adaptive immunity in patients with moderate course of COVID-19 with various degrees of lung tissue damage
- Authors: Skripkinа N.A.1, Sizyakinа L.P.2, Antonova E.A.1, Sizyakin D.V.1, Zakurskayа V.Y.2
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Affiliations:
- Semashko City Hospital No.1
- Rostov State Medical University
- Issue: Vol 19, No 1-4 (2022)
- Pages: 69-74
- Section: Articles
- URL: https://cijournal.ru/1684-7849/article/view/623115
- DOI: https://doi.org/10.17816/CI2022221-4-10
- ID: 623115
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Open Access
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Abstract
Objective: to study changes in innate and adaptive immunity in patients with a moderate course of COVID-19 with varying degrees of lung tissue damage. 40 patients with a moderate form of COVID-19 and varying degrees of damage to the lung tissue (up to 25% and up to 50%) and 30 patients from the control group (healthy donors) were examined using methods: computed tomography of the lungs, evaluation of a complete blood count, biochemical parameters, immunological studies, statistical. Differences in all patients with the control group consisted in a decrease in the absolute content of lymphocytes, in a significant increase in the relative content of natural killers and cytokine imbalance. The most significant differences were registered in the content of IL-6, depending on the degree of damage to the lung tissue. A smaller area of lung damage reflects a milder course of the disease, which does not exclude the need for dispensary observation and rehabilitation after discharge.
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About the authors
Nadezhda A. Skripkinа
Semashko City Hospital No.1
Email: cytokines@yandex.ru
ORCID iD: 0000-0003-0165-6805
infectious disease specialist of the monoinfective hospital
Russian Federation, Rostov-on-DonLudmila P. Sizyakinа
Rostov State Medical University
Author for correspondence.
Email: msiziakina@mail.ru
md, professor, head of the department of clinical immunology and allergology
Russian Federation, 344022, Rostov-on-Don, lane. Nakhichevan, 29Elena A. Antonova
Semashko City Hospital No.1
Email: cytokines@yandex.ru
head of laboratory research quality department
Russian Federation, Rostov-on-DonDmitry V. Sizyakin
Semashko City Hospital No.1
Email: cytokines@yandex.ru
md, professor, professor of the department of urology
Russian Federation, Rostov-on-DonVita Ya. Zakurskayа
Rostov State Medical University
Email: cytokines@yandex.ru
assistant of the department of clinical immunology and allergology
Russian Federation, 344022, Rostov-on-Don, lane. Nakhichevan, 29References
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