The effect of abdominal obesity on the level of inflammatory markers in young people with hypertension
- Authors: Polonskaya Y.V.1, Kashtanova E.V.1, Stakhneva E.M.1, Shramko V.S.1, Sadovski E.V.1, Ledovskikh S.R.1, Khudyakova A.D.1, Ragino Y.I.1
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Affiliations:
- Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
- Issue: Vol 19, No 1-4 (2022)
- Pages: 47-53
- Section: Articles
- URL: https://cijournal.ru/1684-7849/article/view/623111
- DOI: https://doi.org/10.17816/CI2022221-4-8
- ID: 623111
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Abstract
Objective: to investigate pro- and anti-inflammatory blood markers in young people with arterial hypertension (AH) against the background of abdominal obesity (AO).
Materials and methods: the study included 530 people, including 267 people with hypertension, of which 169 were with AO. In the control group (without AH) there were 263 people comparable in gender and age, with AO - 106 people. The content of TNF-α, IL-6, IL-8, MCP-1 (monocytic chemoatractant protein), PAI-1 (plasminogen activator inhibitor-1), IL-10, IL-17a, IL-17e, IL-17f were determined in all blood by multiplex analysis. Statistical processing was carried out in the SPSS 13.0 program.
Results: The level of IL-17a was 1.64 times higher in patients with hypertension (p<0.05) compared to the control. The level of IL-6 in patients with hypertension was higher (p<0.0001) by 52.91% compared to the group without hypertension. There was no difference between the control and the group with hypertension for the remaining biomarkers. The influence of AO on the level of the studied markers in the control group was not revealed. In the group with AH, a significantly higher level of PAI-1 (p<0.05) was in the subgroup with AO. For subgroups with AO, the difference between patients without AH and with AH was manifested in a decrease in IL-17e and an increase in IL-6 in patients with AH (p<0.05). No statistically significant difference was found for the remaining indicators. The relative chance of early hypertension was associated with the presence of AO and an increase in the level of IL-6.
Conclusion: From the markers of inflammation studied by us, an increased level of IL-6 and IL-17a can serve as potential biomarkers indicating a high probability of developing early hypertension in people under 45 years of age.
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About the authors
Yana V. Polonskaya
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Author for correspondence.
Email: yana-polonskaya@yandex.ru
senior researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Elena V. Kashtanova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
head of the laboratory of clinical biochemical and hormonal studies of therapeutic diseases
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Ekaterina M. Stakhneva
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
senior researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Victoria S. Shramko
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Evgeniy V. Sadovski
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
junior researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Sophia R. Ledovskikh
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
resident
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Alena D. Khudyakova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
head of the laboratory of genetic and environmental determinants of the human life cycle
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1Yulia I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM – Branch of IC&G SB RAS)
Email: cytokines@yandex.ru
md, corresponding member of the Russian academy of sciences
Russian Federation, 630089, Novosibirsk, B. Bogatkova str., 175/1References
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