Serum levels of cytokines in patients with retinal neurodegeneration in diabetic retinopathy on the background of type 2 diabetes mellitus
- Authors: Markelova E.V.1, Ruchkin M.P.1,2, Fedyashev G.A.1,2
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Affiliations:
- Pacific State Medical University
- Primorsky Eye Microsurgery Center
- Issue: Vol 19, No 1-4 (2022)
- Pages: 34-37
- Section: Articles
- URL: https://cijournal.ru/1684-7849/article/view/623106
- DOI: https://doi.org/10.17816/CI2022221-4-6
- ID: 623106
Cite item
Abstract
The aim of the present study was to determine the serum level of IL-1β, TNF-α IL-17A, INF-γ, IL-10 in patients with retinal neurodegeneration against the background of type 2 diabetes mellitus. The study included 80 patients with type 2 diabetes mellitus, which were divided into 4 groups depending on the presence of vascular symptoms of diabetic retinopathy and retinal neurodegeneration. The level of cytokines was determined using solid-phase ELISA. In groups of patients with retinal neurodegeneration, a significant (p<0.05) increase in IL-1β and a decrease in IL-10 were detected. The presence of vascular changes in the retina did not affect the level of cytokines studied. The identified changes show the role of systemic imbalance between pro- and anti-inflammatory cytokines in the induction of retinal neurodegeneration in diabetic retinopathy. Further study of this problem is required in order to search for possible immune markers of retinal neurodegeneration in patients with type 2 diabetes.
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About the authors
Elena V. Markelova
Pacific State Medical University
Author for correspondence.
Email: markev2010@mail.ru
ORCID iD: 0000-0001-6632-9800
md, phd, head of department of normal and pathological physiology
Russian Federation, 2 Ostryakova Ave. Vladivostok 690002Mikhail P. Ruchkin
Pacific State Medical University; Primorsky Eye Microsurgery Center
Email: michaelr-n@mail.ru
ORCID iD: 0000-0002-8966-3120
md, phd-student department of normal and pathological physiology
Russian Federation, 2 Ostryakova Ave. Vladivostok 690002; 100e Borisenko str. Vladivostok 690088Gleb A. Fedyashev
Pacific State Medical University; Primorsky Eye Microsurgery Center
Email: fediashev@mail.ru
md, phd, prof. of department of ophthalmology and otorhinolaryngology
Russian Federation, 2 Ostryakova Ave. Vladivostok 690002; 100e Borisenko str. Vladivostok 690088References
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