电邮这篇文章 Modular nanotransporters containing Keap1 monobodies are capable of reducing the toxic effect of acetaminophen on the liver of mice
- 作者: Khramtsov Y.V.1, Rosenkranz A.A.1,2, Ulasov A.V.1, Slastnikova T.А.1, Lupanova T.N.1, Alieva R.T.1, Georgiev G.P.1, Sobolev A.S.1,2
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隶属关系:
- Institute of Gene Biology, RAS
- Lomonosov Moscow State University Moscow
- 期: 卷 521, 编号 1 (2025)
- 页面: 225-228
- 栏目: Articles
- URL: https://cijournal.ru/2686-7389/article/view/684012
- DOI: https://doi.org/10.31857/S2686738925020109
- ID: 684012
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详细
Previously, we created a modular nanotransporter (MNT) containing a monobody to Keap1, an intracellular protein inhibitor of the Nrf2 transcription factor that controls cellular protection from oxidative stress and is capable of interacting with Keap1 in hepatocytes and protect this cells from the effects of hydrogen peroxide. Oxidative liver damage by acetaminophen was used as a model to study the antitoxic effect of this MNT. Intraperitoneal injection of acetaminophen to mice resulted in an increase in the level of alanine aminotransferase and aspartate aminotransferase in the blood, as well as in liver edema. A significant decrease in the level of these enzymes in the blood, along with a decrease in liver edema, was observed after preliminary intravenous administration of MNT 2 hours before the acetaminophen injection. The results obtained can serve as a basis for creating drugs aimed at treating diseases associated with oxidative stress.
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作者简介
Y. Khramtsov
Institute of Gene Biology, RAS
编辑信件的主要联系方式.
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow
A. Rosenkranz
Institute of Gene Biology, RAS; Lomonosov Moscow State University Moscow
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow; Moscow
A. Ulasov
Institute of Gene Biology, RAS
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow
T. Slastnikova
Institute of Gene Biology, RAS
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow
T. Lupanova
Institute of Gene Biology, RAS
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow
R. Alieva
Institute of Gene Biology, RAS
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow
G. Georgiev
Institute of Gene Biology, RAS
Email: alsobolev@yandex.ru
Academician of the RAS
俄罗斯联邦, MoscowA. Sobolev
Institute of Gene Biology, RAS; Lomonosov Moscow State University Moscow
Email: alsobolev@yandex.ru
俄罗斯联邦, Moscow; Moscow
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