Cytokine regulation disbalance: the basis for COVID-19 immunopathogenesis
- Autores: Simbirtsev A.S.1
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Afiliações:
- State Research Institute of Highly Pure Biopreparations
- Edição: Volume 20, Nº 2 (2023)
- Páginas: 12-23
- Seção: Научные обзоры
- URL: https://cijournal.ru/1684-7849/article/view/627301
- DOI: https://doi.org/10.17816/CI627301
- ID: 627301
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Resumo
Coronavirus infection activates two main signaling pathways for type I and III IFN and the gene expression and synthesis of proinflammatory cytokines. These cytokines are required for antiviral defense and inflammatory reaction formation. SARS-CoV-2 coronavirus could inhibit the IFN system by depressing signaling pathways for IFN gene expression, synthesis, and secretion. IFN inhibition should be considered the primary reason for coronavirus escape from the immune system and a key factor for COVID-19 immunopathogenesis. Cytokine regulation disbalance in patients with severe COVID-19 is closely associated with low and delayed IFN synthesis, while proinflammatory cytokine production by macrophages and T-lymphocytes continues simultaneously with intensive virus replication. Thus, the reason for COVID-19 immunopathogenesis is the cytokine regulation disbalance where IFN inhibition and intensive proinflammatory cytokine synthesis lead to cytokine storm, inadequate inflammation, respiratory distress syndrome development, respiratory failure, systemic inflammatory complications, and polyorganic failure.
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Sobre autores
Andrey Simbirtsev
State Research Institute of Highly Pure Biopreparations
Autor responsável pela correspondência
Email: simbas@mail.ru
ORCID ID: 0000-0002-8228-4240
Código SPIN: 2064-7584
MD, Dr. Sci. (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences
Rússia, Saint PetersburgBibliografia
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