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In vitro and in vivo biodegradation of silk fabric scaffolds
- Authors: Agapov I.I.1, Podbolotova E.I.1,2, Nemets E.A.1, Kirsanova L.A.1, Grudinin N.V.1, Pashutin A.R.1,2, Agapova O.I.1, Efimov A.E.1, Basok Y.B.1, Lyundup A.V.3, Gautier S.V.1,4
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Affiliations:
- Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
- Moscow Institute of Physics and Technology
- Рeoples’ Friendship University of Russia
- Sechenov University
- Issue: Vol 520, No 1 (2025)
- Pages: 45-49
- Section: Articles
- URL: https://cijournal.ru/2686-7389/article/view/682031
- DOI: https://doi.org/10.31857/S2686738925010089
- EDN: https://elibrary.ru/tcqqzj
- ID: 682031
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Abstract
This study investigates the biodegradation of natural silk scaffolds made from gauze and satin fabrics under in vitro and in vivo conditions. Experiments were conducted using phosphate-buffered saline and Fenton’s reagent to model degradation. The samples demonstrated high stability under physiological conditions’ model and exhibited varying degradation rates under oxidative stress. In vivo studies on rats revealed good biocompatibility of the scaffolds and a gradual reduction in inflammatory responses. These findings highlight the potential of silk scaffolds for use in various areas of regenerative medicine.
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About the authors
I. I. Agapov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Author for correspondence.
Email: igor.agapov@gmail.com
Russian Federation, Moscow
E. I. Podbolotova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation; Moscow Institute of Physics and Technology
Email: igor.agapov@gmail.com
Russian Federation, Moscow; Dolgoprudny
E. A. Nemets
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor.agapov@gmail.com
Russian Federation, Moscow
L. A. Kirsanova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor.agapov@gmail.com
Russian Federation, Moscow
N. V. Grudinin
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor.agapov@gmail.com
Russian Federation, Moscow
A. R. Pashutin
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation; Moscow Institute of Physics and Technology
Email: igor.agapov@gmail.com
Russian Federation, Moscow; Dolgoprudny
O. I. Agapova
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor.agapov@gmail.com
Russian Federation, Moscow
A. E. Efimov
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor.agapov@gmail.com
Russian Federation, Moscow
Yu. B. Basok
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation
Email: igor.agapov@gmail.com
Russian Federation, Moscow
A. V. Lyundup
Рeoples’ Friendship University of Russia
Email: igor.agapov@gmail.com
Russian Federation, Moscow
S. V. Gautier
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation; Sechenov University
Email: igor.agapov@gmail.com
Academician of the RAS
Russian Federation, Moscow; MoscowReferences
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