Analysis of natural antibodies during the development of phantom pain syndrome
- Authors: Myagkova M.А.1, Petrochenko S.N.1, Bobrova Z.V.1, Orlova E.А.1
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Affiliations:
- Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry Russian Academy of Sciences
- Issue: Vol 517, No 1 (2024)
- Pages: 69-75
- Section: Articles
- URL: https://cijournal.ru/2686-7389/article/view/651419
- DOI: https://doi.org/10.31857/S2686738924040118
- ID: 651419
Cite item
Abstract
We determined natural antibodies (e-Abs) to the regulators of the main systems of biochemical homeostasis: β-endorphin, serotonin, dopamine, histamine, orphanin, angiotensin, GABA, glutamate, bradykinin, vasopressin, thrombin, α-2-macroglobulin in individuals with phantom pain syndrome (FBS), resulting from amputation after injury. It has been established that each patient has an individual immunoprofile, but for all of them there is a significant increase in the level of antibodies to serotonin, histamine and angiotensin, which reflect the chronicity of the pain syndrome and do not depend on the self-assessment of the severity of FBS. Determining the role of regulators of biochemical homeostasis in the development of phantom pain showed that with high, moderate and weak severity of FBS, the biogenic amine and angiotensinergic systems are activated. A decrease in FBS intensity normalizes deviations in all immunological parameters. The level of e-Abs for the pain (β-endorphin) and analgesic (orphanin) systems are significant only at low FBS. Monitoring the individual profile of e-Abs to endogenous regulators allows us to obtain an objective picture of the pain status of the patient’s body.
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About the authors
M. А. Myagkova
Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry Russian Academy of Sciences
Email: dianark@mail.ru
Russian Federation, Chernogolovka, Moscow region
S. N. Petrochenko
Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry Russian Academy of Sciences
Author for correspondence.
Email: dianark@mail.ru
Russian Federation, Chernogolovka, Moscow region
Z. V. Bobrova
Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry Russian Academy of Sciences
Email: dianark@mail.ru
Russian Federation, Chernogolovka, Moscow region
E. А. Orlova
Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry Russian Academy of Sciences
Email: dianark@mail.ru
Russian Federation, Chernogolovka, Moscow region
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Note
Presented by Academician of the RAS S.O. Bachyurin