The Chemoprotective Potentials of Alpha-lipoic Acid against Cisplatin-induced Ototoxicity: A Systematic Review


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Abstract

Purpose:Ototoxicity is one of the major adverse effects of cisplatin therapy which restrict its clinical application. Alpha-lipoic acid administration may mitigate cisplatin-induced ototoxicity. In the present study, we reviewed the protective potentials of alpha-lipoic acid against the cisplatin-mediated ototoxic adverse effects.

Methods:Based on the PRISMA guideline, we performed a systematic search for the identification of all relevant studies in various electronic databases up to June 2022. According to the inclusion and exclusion criteria, the obtained articles (n=59) were screened and 13 eligible articles were finally included in the present study.

Results:The findings of in-vitro experiments showed that cisplatin treatment significantly reduced the auditory cell viability in comparison with the control group; nevertheless, the alpha-lipoic acid co-administration protected the cells against the reduction of cell viability induced by cisplatin treatment. Moreover, the in-vivo results of the auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests revealed a decrease in DPOAE and an increase in ABR threshold of cisplatin-injected animals; however, it was shown that alpha-lipoic acid co-treatment had an opposite pattern on the evaluated parameters. Other findings demonstrated that cisplatin treatment could significantly induce the biochemical and histopathological alterations in inner ear cells/tissue; in contrast, alpha-lipoic acid co-treatment ameliorated the cisplatin-mediated biochemical and histological changes.

Conclusion:The findings of audiometry, biochemical parameters, and histological evaluation showed that alpha-lipoic acid co-administration alleviates the cisplatin-induced ototoxicity. The protective role of alpha-lipoic acid against the cisplatin-induced ototoxicity can be due to different mechanisms of anti-oxidant, anti-apoptotic, anti-inflammatory activities, and regulation of cell cycle progression.

About the authors

Rahman Zabibah

Medical Laboratory Technology Department, College of Medical Technology,, The Islamic University

Email: info@benthamscience.net

Jitendra Gupta

Institute of Pharmaceutical Research, GLA University

Email: info@benthamscience.net

Muhammad Iqbal

Department of Clinical Pharmacy, College of Pharmacy,, Prince Sattam Bin Abdulaziz University

Email: info@benthamscience.net

Acim Iswanto

Public Health Department, Faculty of Health Science,, University of Pembangunan Nasional Veteran Jakartaatan

Email: info@benthamscience.net

Bagher Farhood

Department of Medical Physics and Radiology, Faculty of Paramedical Sciences,, Kashan University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Ghaidaa Lateef Al-Awsi

College of Science, University of Al-Qadisiyah

Email: info@benthamscience.net

Uzma Arshed

, Gujranwala medical college

Email: info@benthamscience.net

Anam Arif

, Gujranwala medical college

Email: info@benthamscience.net

Andrés Ramírez-Coronel

Epidemiology and Biostatistics Research Group, CES University

Email: info@benthamscience.net

Muataz Alhassan

Division of Advanced Nanomaterial Technologiesentific Research Center, Scientific Research Center, Al-Ayen University

Email: info@benthamscience.net

Yasser Mustafa

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul

Email: info@benthamscience.net

Ferry Rahman

Public Health Department, Universitas Muhammadiyah Kalimantan Timur

Email: info@benthamscience.net

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