Challenges of Natural Anticancer and Anti-inflammatory Agents


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About the authors

Marcus Scotti

Cheminformatics Laboratory- Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba,

Email: info@benthamscience.net

Luciana Scotti

Teaching and Research Management - University Hospital Cheminformatics Laboratory- Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba,

Email: info@benthamscience.net

References

  1. Cavalcanti, E.; Felix, M.B.; Scotti, L.; Scotti, M.T. Virtual screening of natural products to select compounds with potential anticancer activity. Anticancer. Agents Med. Chem., 2019, 19(2), 154-171. doi: 10.2174/1871520618666181119110934
  2. de Araujo, R.S.A.; da Silva, E.F.; de Aquino, T.M.; Scotti, M.T.; Ishiki, H.M.; Scotti, L.; Mendonca, F.J.B. Computer-aided drug design applied to secondary metabolites as anticancer agents. Curr. Top. Med. Chem., 2020, 20(19), 1677-1703. doi: 10.2174/1568026620666200607191838
  3. De, B.; Bhandari, K.; Mendonca, F.J.B.; Scotti, M.T.; Scotti, L. Computational studies in drug design against cancer. Anticancer. Agents Med. Chem., 2019, 19(5), 587-591. doi: 10.2174/1871520618666180911125700
  4. Gouveia, D.N.; Costa, J.S.; Oliveira, M.A.; Rabelo, T.K.; Silva, A.; Carvalho, A.A.; Miguel-dos-Santos, R.; Lauton-Santos, S.; Scotti, L.; Scotti, M.T. Alpha-terpineol reduces cancer pain via modulation of oxidative stress and inhibition of iNOS. Biomed. Pharmacother., 2018, 105, 652-661. doi: 10.1016/j.biopha.2018.06.027
  5. Guimaraes, A.G.; Scotti, L.; Scotti, M.T.; Mendonca, F.J.B.; Melo, N.S.R.; Alves, R.S.; De Lucca, W.; Bezerra, D.P.; Gelain, D.P.; Quintans, L.J. Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study. Life Sci., 2014, 116(1), 8-15. doi: 10.1016/j.lfs.2014.08.020
  6. Kleandrova, V.V.; Scotti, M.T.; Scotti, L.; Nayarisseri, A.; Speck-Planche, A. Cell-based multi-target QSAR model for design of virtual versatile inhibitors of liver cancer cell lines. Sar and Qsar Environ. Res., 2020, 31(11), 815-836. doi: 10.1080/1062936x.2020.1818617
  7. Pina, L.T.S.; Rabelo, T.K.; Trindade, G.G.G. Gamma-terpinene complexed with beta-cyclodextrin attenuates spinal neuroactivity in animals with cancer pain by Ca2+ channel block. J. Pharm. Pharmacol., 2022, 74(11), 1629-1639. doi: 10.1093/jpp/rgac052
  8. Santos, W.B.R.; Melo, M.A.O.; Alves, R.S. p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents. Phytomed., 2019, 61 doi: 10.1016/j.phymed.2019.152836
  9. Scotti, L.; Scotti, M.T.; Ishiki, H.; Junior, F.; dos Santos, P.F.; Tavares, J.F.; da Silva, M.S. Prediction of anticancer activity of diterpenes isolated from the paraiban flora through a PLS model and molecular surfaces. Nat. Prod. Commun., 2014, 9(5), 609-612.

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