Hydrogen Sulfide: Physiological Roles and Therapeutic Implications against COVID-19


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Abstract

The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) poses a major menace to economic and public health worldwide. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are two host proteins that play an essential function in the entry of SARS-- COV-2 into host cells. Hydrogen sulfide (H2S), a new gasotransmitter, has been shown to protect the lungs from potential damage through its anti-inflammatory, antioxidant, antiviral, and anti-aging effects. It is well known that H2S is crucial in controlling the inflammatory reaction and the pro-inflammatory cytokine storm. Therefore, it has been suggested that some H2S donors may help treat acute lung inflammation. Furthermore, recent research illuminates a number of mechanisms of action that may explain the antiviral properties of H2S. Some early clinical findings indicate a negative correlation between endogenous H2S concentrations and COVID-19 intensity. Therefore, reusing H2S-releasing drugs could represent a curative option for COVID-19 therapy.

About the authors

Sajad Abolfazli

Student Research Committee, School of Pharmacy, Mazandaran University of Medical Science

Email: info@benthamscience.net

Nima Ebrahimi

Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Etekhar Morabi

Student Research Committee, School of Pharmacy, Shahid Sadoughi University of Medical Science

Email: info@benthamscience.net

Mohammad Asgari Yazdi

Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Gokhan Zengin

Department of Biology, Science Faculty, Selçuk University

Email: info@benthamscience.net

Thozhukat Sathyapalan

Academic Diabetes, Endocrinology and Metabolism, University of Hull

Email: info@benthamscience.net

Tannaz Jamialahmadi

Applied Biomedical Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Amirhossein Sahebkar

Applied Biomedical Research Center, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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