Enviar artigo por via de e-mail INFLUENCE OF POTASSIUM BICHROMATE ON MORPHOLOGICAL AND IMMUNOLOGICAL CHARACTERISTICS OF WISTAR RATS
- Autores: Smolyagin A.I.1, Mikhaylova I.V.1, Ermolina E.V.1, Stadnikov A.A.1, Boev V.M.1
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Afiliações:
- State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
- Edição: Nº 2 (2015)
- Páginas: 40-44
- Seção: Articles
- ##submission.datePublished##: 06.04.2015
- URL: https://cijournal.ru/0869-7922/article/view/641321
- DOI: https://doi.org/10.15690/vramn448
- ID: 641321
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Resumo
The impact of Potassium Bichromate ( at 1 MAC dose) on morphological and immunological parameters of Wistar rats lymphoid organs was investigated in a chronic experiment (135 days). A lasting uptake of chromium by the Wistar rat organism induces a decrease of thymus mass and thymocytes number, causes a complex of structural and functional alterations evidencing about the status of accidental involution, lymphoreticular hyperplasia and plasmocytic and macrophage transformation of lymphoid nodes and spleen, induces a programmed death of thymocytes and lymphocytes in splenic T-zones and lymphoid nodes. Chromium induces morpho-functional changes in spleen shown by decrease in its weight and number of spelnocytes, lymphoid series cells and on the contrary by increase of erythroid series cells. The impact of chromium on the bone marrow was evident in a decreased level of myeloid series, neutrophils and on the contrary in increased amount of lymphoid cells and the content of erythroid cells as well.
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Sobre autores
Aleksandr Smolyagin
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Autor responsável pela correspondência
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, заведующий проблемной лабораторией по изучению механизмов естественного иммунитета Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: probllab.orenburg@mail.ru
RússiaIrina Mikhaylova
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор биологических наук, доцент кафедры химии и фармацевтической химии Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: michaylova74@yandex.ru
RússiaEvgenija Ermolina
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Кандидат биологических наук, старший научный сотрудник проблемной лаборатории по изучению механизмов естественного иммунитета Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: probllab.orenburg@mail.ru
RússiaAleksandr Stadnikov
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор биологических наук, профессор, заведующий кафедрой гистологии, цитологии эмбриологии, 460000, г. Оренбург
e-mail: k_histology@orgma.ru
RússiaViktor Boev
State Budgetary Educational Institution «Orenburg State Medical Academy», Ministry of Health of Russia
Email: noemail@neicon.ru
Доктор медицинских наук, профессор, ректор Оренбургской государственной медицинской академии Минздрава РФ, 460000, г. Оренбург
e-mail: probllab.orenburg@mail.ru
RússiaBibliografia
- Revich B.A. To assess the impact of FEC on the environment and human health. Problemy prognozirovanija. 2010; 4:87-99 (in Russian).
- GN 2.1.5.2280-07. Maximum permissible concentration (MPC) of chemicals in water of the economydrinking and cultural-everyday objects. Moscow : Rospotrebnadzor; 2008 (in Russian).
- Kiyasov A.P. Modern technology of the morphological studies: Toolkit for students, post-graduate and doctors-pathologists. Kazan’: KGMU; 2001 (in Russian).
- Volchegorsky I.A., Dolgushin I.I., Kolesnikov O.L., Cejlikman V.Je. Experimental modeling and laboratory evaluation of the adaptive reactions. Cheljabinsk: ChGPU; 2000 (in Russian).
- Yarilin A.A. Immunology. Moscow: GEOTAR-Media; 2010 (in Russian).
- Kurlyandskiy B.A., Filov V.A., red. General Toxicology. Moscow: Meditsina; 2002 (in Russian).
- O’Brien, P., Kortenkamp A. Chemical models important in understanding the ways in which chromate can damage DNA. Environ Health Perspect. 1994; 102 (3): 3-10.
- Iztleutov M.K. Patogenez of violations of the homeostasis caused by excess intake of chrome in an organism, and ways of their correction: Dr. med. sci. diss. Moscow ; 2004 (in Russian).
- Valko M., Morris H., Cronin M. T. Metals, toxicity and oxidative stress. Curr. Med. Chem. 2005; 12:1161-1208.
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