EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

Data on the biological activity of kappa-opioid receptor agonists - derivatives of three groups of compounds: 1,2-cyclohexylamine, 1,2,3,4-piperidine, 1,2,4-piperazine are presented. On the examples of 1,2-cyclohexylamine and 1,2,4-piperazine derivatives, it has been shown that a decrease in the length of the carbon chain in the phenylalkyl substituent at the nitrogen atom is accompanied by a decrease in the analgesic activity and toxicity of compounds. The replacement of chlorine atoms in the 3 and 4 positions of the phenyl ring with fluorine atoms, which are more electronegative, leads to an increase in the analgesic effect and a decrease in the toxicity of the compounds.

Авторлар туралы

S. Chepur

State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation

Хат алмасуға жауапты Автор.
Email: gniiivm_15@mil.ru

Chepur Sergei Viktorovich

195043, Saint Petersburg

Ресей

S. Galan

State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation

Email: gniiivm_15@mil.ru

Galan Sergei Evgenievich

195043, Saint Petersburg

Ресей

M. Vakhviayanen

State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation

Email: gniiivm_15@mil.ru

Vakhviayanen Maria Sergeevna

195043, Saint Petersburg

Ресей

R. Khromov

State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation

Email: gniiivm_15@mil.ru

Khromov Roman Nikolaevich

195043, Saint Petersburg

Ресей

A. Semenov

State Scientific Research Testing Institute of Military Medicine, Ministry of Defence of the Russian Federation

Email: gniiivm_15@mil.ru

Semenov Alexander Nikolaevich

195043, Saint Petersburg

Ресей

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© Chepur S.V., Galan S.E., Vakhviayanen M.S., Khromov R.N., Semenov A.N., 2020


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