Mitochondrial DNA Deletions in Peripheral Blood of Offspring of Workers Occupationally Exposed to Chronic Ionizing Radiation

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Abstract

Deletions in mitochondrial DNA are recognized factors in mitochondrial disorders and aging. The aim of this study was to investigate the prevalence of large-scale mtDNA deletions in peripheral blood samples of offspring whose parents, "Mayak" PA workers, were exposed to combined external γ- and internal α-radiation during the preconception period. Using long-extension PCR, deletions of 4977 bp and sizes ranging from 7436 to 8044 bp were detected. It was found that the prevalence of deletions in the studied groups of these offspring tended to increase, but no statistically significant differences were found compared to the control group.

About the authors

M. G Lomaeva

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Pushchino, Russia

M. L Zakharova

Southern Urals Federal Research and Clinical Center for Medical Biophysics of the Federal Medical Biological Agency of Russian Federation

Ozyorsk, Russia

T. V Azizova

Southern Urals Federal Research and Clinical Center for Medical Biophysics of the Federal Medical Biological Agency of Russian Federation

Ozyorsk, Russia

V. N Antipova

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: valery_a@rambler.ru
Pushchino, Russia

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