Comparative Analysis of Sensitizing Activity and Biodistribution Characteristics of Chlorin e6 Derivatives: Influence of the Nature of Charged Groups

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Abstract

New data have been obtained that expand the understanding of the role of the chemical structure and physico-chemical properties of photosensitizer molecules in determining the processes of their interaction with various biological objects, including serum proteins, biological membranes, cells and cellular systems. Changes in the side substituents in the chlorin e6 molecule significantly affect the physico-chemical properties of new compounds, the level of their accumulation in cells, and the rate of migration between cells, but do not significantly affect the intracellular localization of sensitizers. It is assumed that the increased photosensitizing activity of chlorin e6 derivatives is due to the influence of lateral substituents on their biodistribution processes.

About the authors

T. E Zorina

Belarusian State University

Email: zorinate@mail.ru
Minsk, Belarus

T. I Ermilova

Republican Scientific and Practical Center for Pediatric Oncology, Hematology and Immunology

Belarus

I. V Kablov

Belarusian State University

Minsk, Belarus

I. E Kravchenko

Belarusian State University

Minsk, Belarus

T. V Shman

Republican Scientific and Practical Center for Pediatric Oncology, Hematology and Immunology

Minsk region, Belarus

T. V Kustova

Ivanovo State University of Chemical Technology

Ivanovo, Russia

D. B Berezin

Ivanovo State University of Chemical Technology

Ivanovo, Russia

I. S Khudyaeva

Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences

Syktyvkar, Russia

V. P Zorin

Belarusian State University; International Sakharov Environmental Institute of the Belarusian State University

Minsk, Belarus; Minsk, Belarus

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