Cytokines and inflammationCytokines and inflammationЦитокины и воспаление1684-7849Eco-Vector70543410.17816/CI705434JVBSFUOriginal Study ArticlesОригинальные исследованияResearch ArticleLipoxygenases and CFTR inhibitory factors might share the same role in host–microbe interactionsЛипоксигеназы и CFTR-ингибирующие факторы могут играть одинаковую роль во взаимодействии «микроорганизм — хозяин»https://orcid.org/0000-0002-5484-82647543-2903KurakinGeorgy F.КуракинГеоргий Фёдорович
Russian Federation

Independent researcher

Независимый исследователь

phyzyk@mail.ru220720260408202623143570304202608072026Copyright ©; 2026, Kurakin G.F.Copyright ©; 2026, Куракин Г.Ф.2026Kurakin G.F.Куракин Г.Ф.https://creativecommons.org/licenses/by-nc-nd/4.0/https://cijournal.ru/1684-7849/article/view/705434

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel in humans and other vertebrates, whose mutation leads to cystic fibrosis. CFTR inhibitory factor, or Cif, is a recently discovered bacterial epoxide hydrolase that downregulates CFTR protein upon the bacterial infection. However, its cleaving activity has been recently characterized towards fatty acid epoxides—epoxygenase-derived oxylipins. We identified a list of host-associated bacteria with putative Cif proteins, identified their most prevalent ecological functions within a systematic review, and performed similar review for the previously assembled list of host-associated bacteria carrying lipoxygenase (LOX). Both Cif and LOX showed the association with pathogenesis and symbiosis in broad host range, and similar ecological profiles of their carriers suggested that they both might target oxylipin signaling in hosts. We also described the association of Cif with plant hormone biosynthesis and plant growth promotion, which indirectly supports our previous model of bacterial LOX action in plant and vertebrate hosts.

Трансмембранный регулятор проводимости при муковисцидозе (CFTR; от англ. cystic fibrosis transmembrane conductance regulator) — это хлоридный канал человека и других позвоночных, мутация в гене которого приводит к муковисцидозу. CFTR-ингибирующий фактор (Cif) — это недавно открытая бактериальная эпоксидгидролаза, снижающая количество молекул белка CFTR на поверхности клетки при бактериальной инфекции. Однако недавно была также охарактеризована его способность расщеплять эпоксиды жирных кислот — оксилипины, образующиеся по эпоксигеназному пути. Мы идентифицировали бактерии, ассоциированные с каким-либо хозяином и потенциально содержащие Cif, выявили наиболее распространённые экологические функции путём систематического обзора литературы, а также выполнили аналогичный обзор для ранее составленного списка бактерий, связанных с каким-либо хозяином и имеющих липоксигеназу. Как Cif, так и липоксигеназа продемонстрировали ассоциацию с патогенностью и симбиотическим потенциалом в отношении широкого круга хозяев, а сходные экологические профили бактерий-носителей позволили предположить, что оба фермента могут влиять на оксилипиновую сигнализацию хозяев. Мы также описали ассоциацию Cif с биосинтезом фитогормонов и стимуляцией роста растений, что косвенно подтверждает ранее выдвинутую нами гипотезу о механизме действия бактериальных липоксигеназ на растения и позвоночных.

lipoxygenaseCFTR inhibitory factorCifoxylipinshost-microbe interactionsnosocomial pathogenscystic fibrosisplantsлипоксигеназаCFTR-ингибирующий факторCifоксилипинывзаимоотношения «микроорганизм — хозяин»нозокомиальные патогенымуковисцидозрастения

This is an original paper which was previously published as a preprint on Preprints.org server under the DOI: https://doi.org/10.20944/preprints202602.1829.v1 Depositing papers on the preprint servers is considered a legitimate research practice.

Это оригинальная статья, которая ранее была опубликована в виде препринта на сервере Preprints.org (DOI: https://doi.org/10.20944/preprints202602.1829.v1). Размещение статей на серверах препринтов считается легитимной исследовательской практикой.

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