TRANSGENERATIONAL EFFECTS OF VINYL CHLORIDE

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The impact of vinyl chloride (inhalation exposure at a mean concentration of 1947 mg/m3 during 5 weeks) on the offspring of exposed male rats and intact female rats was studied. The examination of sexually mature offspring included studying behavior in the open field and DNA damage investigation using brain homogenate with DNAcomet assay. It is revealed an increased orienting-exploratory behavior and decrease in the locomotor activity as well as increased DNA damage in the nervous tissue cells as compared with the control animals group .

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Ekaterina Kapustina

Federal State Budgetary Institution «East-Siberian Scientific Center for Human Ecology», Siberian Branch of the Russian Academy of Medical Sciences

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Email: kapustinkaE@yandex.ru

Кандидат медицинских наук, научный сотрудник лаборатории ФГБУ ВСНЦ ЭЧ» СО РАМН, 665827, Иркутская область, г. Ангарск

e-mail: kapustinkaE@yandex.ru

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参考

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