EFFECT OF POLYMORPHISM OF THE GABRA2 GENE ON THE DEGREE OF RAT POISONING IN ACUTE ETHANOL INTOXICATION

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Abstract

Four polymorphic GABRA2 gene variations: rs105733011, rs8168342, rs198286814, rs198837638 that can influence the formation of different biological effects of the organism when exposed to ethanol have been investigated. For rs105733011 polymorphism the frequency of occurrence of the CT genotype was found to be significantly higher (p < 0,05) among animals with «severe intoxication» – 37,0% than with «mild intoxication» – 14,0%. For rs198286814 polymorphism the tendency to the most frequent occurrence of the AG genotype in the group of animals with «severe intoxication» was established. Significant differences in the distribution of occurrence frequencies of the GG/AG genotypes in the studied groups for polymorphic loci rs8168342 and rs198837638 were not revealed. It was concluded that the rs105733011 polymorphism can be one of the genetic markers allowing to predict the degree of inhibitory action of ethanol in acute alcohol intoxication.

About the authors

N. S. Osechkina

Scientific Center «Signal»

Author for correspondence.
Email: dunats@rambler.ru

Osechkina Natal’ya Sergeevna

107014, Moscow

Russian Federation

G. V. Nazarov

Scientific Center «Signal»

Email: fake@neicon.ru

Nazarov Georgiy Valer’evich

107014, Moscow

Russian Federation

M. B. Ivanov

Institute of Toxicology, Federal Medical Biological Agency

Email: m.b.ivanov@toxicology.ru

Ivanov Maksim Borisovich

192019, Saint Petersburg

Russian Federation

E. G. Batotsyrenova

Institute of Toxicology, Federal Medical Biological Agency

Email: fake@neicon.ru

Batotsyrenova Ekaterina Gennad’evna

192019, Saint Petersburg

Russian Federation

V. A. Kashuro

Institute of Toxicology, Federal Medical Biological Agency

Email: fake@neicon.ru

Kashuro Vadim Anatol’evich

192019, Saint Petersburg

Russian Federation

N. V. Lapina

Institute of Toxicology, Federal Medical Biological Agency

Email: fake@neicon.ru

Lapina Natal’ya Vadimovna

192019, Saint Petersburg

Russian Federation

O. V. Varlamova

Scientific Center «Signal»

Email: fake@neicon.ru

Varlamova Olga Vyacheslavovna

107014, Moscow

Russian Federation

I. S. Kravtsov

Scientific Center «Signal»

Email: fake@neicon.ru

Kravtsov Ivan Sergeevich

107014, Moscow

Russian Federation

A. V. Babkin

Scientific Center «Signal»

Email: fake@neicon.ru

Babkin Aleksandr Vladimirovich

107014, Moscow

Russian Federation

A. S. Kraeva

Scientific Center «Signal»

Email: fake@neicon.ru

Kraeva Anna Sergeevna

107014, Moscow

Russian Federation

A. S. Melekhova

Institute of Toxicology, Federal Medical Biological Agency

Email: fake@neicon.ru

Melehova Aleksandra Sergeevna

192019, Saint Petersburg

Russian Federation

K. O. Voitsekhovich

Institute of Toxicology, Federal Medical Biological Agency

Email: fake@neicon.ru

Voicehovih Karina Olegovna

192019, Saint Petersburg

Russian Federation

D. S. Lisitskii

Institute of Toxicology, Federal Medical Biological Agency

Email: fake@neicon.ru

Lisitskii Dmitrii Sergeevich

192019, Saint Petersburg

Russian Federation

References

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Copyright (c) 2019 Osechkina N.S., Nazarov G.V., Ivanov M.B., Batotsyrenova E.G., Kashuro V.A., Lapina N.V., Varlamova O.V., Kravtsov I.S., Babkin A.V., Kraeva A.S., Melekhova A.S., Voitsekhovich K.O., Lisitskii D.S.


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