Prospects for Infrared Luminescent Diagnostics of Superficially

I. P. Shilov; Шилов И. П.; V. D. Rumyantseva; Румянцева В. Д.; A. V. Ivanov; Иванов А. В.; Yu. V. Alekseev; Алексеев Ю. В.; A. S. Gorshkova; Горшкова А. С.; M. V. Ryabov; Рябов М. В.; A. M. Kovaleva; Ковалева А. М.; M. I. Kovalev; Ковалев М. И.

doi:10.31857/S0033849423030130

Prospects for Infrared Luminescent Diagnostics of Superficially

Authors: Shilov I.P.¹, Rumyantseva V.D.¹, Ivanov A.V.²^,3, Alekseev Y.V.³, Gorshkova A.S.¹, Ryabov M.V.³, Kovaleva A.M.⁴, Kovalev M.I.⁵
Affiliations:
1. Kotelniov Institute of Radioengineering and Electronics, Fryazino Branch, Russian Academy of Science
2. National Medical Research Center of Oncology
3. Skobelin Scientific and Practical Center for Laser Medicine, Federal Medical-Biological Agency
4. Pletnev City Clinical Hospital
5. Sechenov First Moscow State Medical University
Issue: Vol 68, No 4 (2023)
Pages: 399-406
Section: ПРИМЕНЕНИЕ РАДИОТЕХНИКИ И ЭЛЕКТРОНИКИ В БИОЛОГИИ И МЕДИЦИНЕ
URL: https://cijournal.ru/0033-8494/article/view/650565
DOI: https://doi.org/10.31857/S0033849423030130
EDN: https://elibrary.ru/IDRXEU
ID: 650565

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Abstract

In this paper, we developed a promising technique for luminescent infrared (IR) diagnostics of neoplasms of visually and endoscopically accessible localization (dermatology, gynecology, dentistry) using ytterbium complexes of porphyrins. Possible mechanisms of accumulation of a pharmaceutical composition based on the ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP) in tumor tissues were studied. Studies on the pharmacokinetics and biodistribution of this substance in various organs and neoplasms of laboratory animals showed a significant selectivity of the accumulation of nanoparticles with ytterbium ions in tumors as early as 24 h after intravenous administration. For the purposes of luminescent IR diagnostics, a highly sensitive laser-fiber fluorimeter operating in the spectral range of 900–1100 nm was developed. Preclinical tests of the developed method of fluorescent IR cancer diagnostics were carried out and its prospects were shown.

Keywords

luminescent infrared diagnostics, ytterbium complexes of porphyrins, highly sensitive laser-fiber fluorimeter

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