Evaluation of the Applicability of External X-ray Radiation to Stimulate the Autoradiolysis Processes in Therapeutic Radiopharmaceuticals (Exemplified by [153Sm]Sm-PSMA-617 and [177Lu]Lu-PSMA-617)

Yu. A. Mitrofanov; Митрофанов Ю. А.; V. B. Bubenshchikov; Бубенщиков В. Б.; A. V. Belousov; Белоусов А. В.; A. S. Lunev; Лунёв А. С.; A. A. Larenkov; Ларенков А. А.

doi:10.31857/S0023119323010096

Evaluation of the Applicability of External X-ray Radiation to Stimulate the Autoradiolysis Processes in Therapeutic Radiopharmaceuticals (Exemplified by [153Sm]Sm-PSMA-617 and [177Lu]Lu-PSMA-617)

Autores: Mitrofanov Y.A.¹, Bubenshchikov V.B.¹, Belousov A.V.¹, Lunev A.S.¹, Larenkov A.A.¹
Afiliações:
1. State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Edição: Volume 57, Nº 1 (2023)
Páginas: 28-38
Seção: RADIATION CHEMISTRY
URL: https://cijournal.ru/0023-1193/article/view/661529
DOI: https://doi.org/10.31857/S0023119323010096
EDN: https://elibrary.ru/DCWVPG
ID: 661529

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Resumo

The paper presents the results of a study on the radiolytic degradation of vector molecules in radiopharmaceuticals, caused by ionizing radiation from the radionuclide used in the preparations, in comparison with the equal dose of external X-ray irradiation. The dose factors for therapeutic radionuclides samarium-153 and lutetium-177 in aqueous solutions were estimated in geometry simulating the finished dosage form of radiopharmaceuticals (standard injection vial ) both by computational methods (in silico) and applying chemical dosimetry. Irradiation with external X-ray source to doses formed in volume of therapeutic radiopharmaceuticals with given radioactivity concentration was performed on an LNK-268 X-ray unit. Using the [153Sm]Sm-PSMA-617 and [177Lu]Lu-PSMA-617 radiopharmaceuticals as an instance, we compared the degree of radiolytic degradation and the profiles of radiolytic impurities formed as a result of both external X-ray irradiation and autoradiolysis. Qualitative coincidence of the impurity profiles formed in both cases was noted. It has been shown that external X-ray radiation can be used to simulate the autoradiolysis processes of radiopharmaceuticals if additional corrections are made for the type of radiation and dose rate.

Palavras-chave

dosimetry, radiolysis, radiopharmaceutical, 177Lu, 153Sm, PSMA-617, simulation, radiochemical purity

Bibliografia

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